Search results for "pathology [Gray Matter]"

Tödliche Hundebisse im Sektionsgut rechtsmedizinischer Institute

2001

Hundebisse werden im angelsachsischen Raum als ernstes medizinisches, soziales und legislatorisches Problem angesehen, wohingegen in der deutschsprachigen Literatur nahezu keine Angaben uber die Inzidenz derartiger, insbesondere letal ausgehender Verletzungen zu finden sind. Zur Gewinnung von Daten uber todliche Hundebiss-Vorfalle in einem ungefahr 10 Jahre umfassenden Zeitraum wurde ein Fragebogen an alle rechtsmedizinischen Institute in Deutschland, der Schweiz und Osterreich versandt. Aus 13 Instituten wurden 20 Falle berichtet, unter denen 11-mal als Todesursache Verbluten und 3-mal eine schwere Infektion genannt wurden. Funfmal war es zu einem Schadel-Hirn-Trauma und 7-mal zu einer Hal…

Unfallflucht und Kopflosigkeit

1963

Extranodal extension of lymph node metastasis is a marker of poor prognosis in oesophageal cancer: A systematic review with meta-analysis

2016

The extranodal extension (ENE) of nodal metastasis is the extension of neoplastic cells through the nodal capsule into the perinodal adipose tissue. This histological feature has recently been indicated as an important prognostic factor in different types of malignancies; in this manuscript, we aim at defining its role in the prognosis of oesophageal cancer with the tool of meta-analysis. Two independent authors searched SCOPUS and PubMed until 31 August 2015 without language restrictions. The studies with available data about prognostic parameters in subjects with oesophageal cancer, comparing patients with the presence of ENE (ENE+) versus only intranodal extension (ENE-), were considered…

Mothers who killed or attempted to kill their child: life circumstances, childhood abuse, and types of killing.

1999

The objectives of the present study were to examine the life circumstances, childhood abuse, and types of homicidal acts of 48 mothers who killed/attempted to kill their children) under age 12 between 1970-96 in Finland. Data on the mothers’ life stresses, psychological problems, and childhood abuse were collected from mental state examination (MSE) reports. The cases were divided into 15 neonaticides and 33 mothers who killed an older child. Childhood abuse was documented in 63% of the mothers’ MSE reports. Qualitative analysis identified neonaticides, joint homicide-suicide attempts, impulsive aggression, psychotic acts, postpartum depression, and abusive acts. Nonlinear principal compone…

The predictive and incremental validity of the German adaptation of the Static-2002 in a sexual offender sample released from the prison system

2015

Purpose The aim of this study was to examine the predictive validity of the German adaptation of the Static-2002 and to compare it with the results of the Static-99. Method The predictive validity of Static-2002 was investigated in a sample of n = 452 sexual offenders released from the Austrian Prison System. The instrument was coded retrospectively using file information. Afterwards, the predictive estimates of the Static-2002 were related to officially documented reconviction data. Results The Static-2002 was found to have large effect sizes for predicting sexual, violent, and general recidivism (area under the receiver operating characteristic curve [AUC] = .78, .75, .75, respectively) f…

Molecular Alterations of the RBI, TP53, and MDM2 Genes in Primary and Xenografted Human Osteosarcomas

1997

We report the status of the RBI, TP53, and MDM2 genes in human osteosarcomas and cell lines established from surgical specimens and transplanted into athymic naked mice. By using reverse transcriptase-polymerase chain reaction (RT-PCR) as a prescreening technique and posterior sequencing, we observe

Ischemic Preconditioning: Postischemic Structural Changes in the Brain

2008

Ischemic brain damage can be prevented or at least significantly reduced when there is a preceding brief ischemic period that does not exceed the threshold for tissue damage--a phenomenon termed "ischemic preconditioning" (ischemic PC). Experimental PC in rodents is now considered to be a model for transient ischemic attacks in humans, and there is increasing hope for translating the knowledge of underlying mechanisms in the animal models into the clinic to enhance endogenous neuroprotective mechanisms in patients with stroke. However, although PC was originally defined as a subtoxic stimulus without any morphologic damage, there is a growing body of evidence from studies using sensitive te…

Differentiation-associated apoptosis of neural stem cells is effected by Bcl-2 overexpression: impact on cell lineage determination

2001

Apoptosis is an integral part of neural development. To elucidate the importance of programmed cell death on cell lineage determination we utilized murine PCC7-Mzl cells, a model system for neural differentiation. Treatment of pluripotent PCC7-Mzl stem cells with 0.1 microM all-trans retinoic acid (RA) causes a cease of proliferation and an initiation of differentiation into neurons, glial cells and fibroblasts. Simultaneously, a fraction of the cell culture (ca. 25%) dies within 24 h by apoptosis. We transfected PCC7-Mzl cells with the human bcl-2 cDNA and generated PCC7-Mz-Bcl-2 cell lines expressing two- to tenfold higher levels of Bcl-2 than parental cells. Overexpression of Bcl-2 resul…

Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes

2008

Apoptosis, or programmed cell death, regulates tissue development and homeostasis in multi-cellular organisms. Extrinsic or intrinsic death signals activate pro-apoptotic pathways, resulting in the activation of caspases and finally in cell death. An important event during apoptosis process is the permeabilization of the outer mitochondrial membrane (OMM). Integrity of the OMM is regulated by the Bcl-2 protein family, which is divided into three groups: anti-apoptotic members Bcl-2, Bcl-xL and myeloid cell leukemia-1 (Mcl-1), pro-apoptotic multidomain members Bax and Bak, and pro-apoptotic BH3-only proteins. Mitochondrial activation is regulated by selective interactions of Bcl-2 proteins v…

Characterization of cells with different mitochondrial membrane potential during apoptosis.

2005

Background Until now, the simultaneous analysis of several parameters during apoptosis, including DNA content and mitochondrial membrane potential (ΔΨ), has not been possible because of the spectral characteristics of the commonly used dyes. Using polychromatic flow cytometry based upon multiple laser and UV lamp excitation, we have characterized cells with different ΔΨ during apoptosis. Methods U937 cells were treated with the flavonoid quercetin (Qu) and stained with JC-1 to detect ΔΨ, propidium iodide (PI) for cell viability, Hoechst 33342 for DNA content, Annexin V conjugated with Alexa Fluor-647 for detection of phosphatidilserine (PS) exposure, marker of early apoptosis, or Mitotracke…